Results

The Active Prevention & Treatment of Maternal Sepsis (APT-Sepsis) Program acheived a 32% reduction in maternal infection-related mortality or severe morbidity.

Primary Outcome

The Active Prevention & Treatment of Maternal Sepsis (APT-Sepsis) Program acheived a 32% reduction in maternal infection-related mortality or severe morbidity. The improvements seen were consistent across countries and facility size and was sustained throughout the trial.

RR: 0.68 (95% CI 0.55, 0.83) P<0.001

1.9% in usual care clusters

2208 women with outcome/116596 live births

1.4% in intervention clusters

1752 women with outcome/124298 live births

The primary outcome was a composite of maternal infection-related mortality or severe morbidity (infection-related maternal near miss, deep surgical-site infection, or body-cavity infection) among pregnant or recently pregnant women. After the baseline period, health facilities had 3 months of transition to allow for training of champions and embedding of the intervention into hospital systems, with an overall 12‑month implementation phase. I bars indicate the 95% confidence interval.